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KMID : 0380319700040000097
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Journal of Korean Research Institute for Better Living
1970 Volume.4 No. 0 p.97 ~ p.101
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Effects of Hypervitaminosis A on Developing Rat Embryos
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Abstract
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An administration of excessive vitamin A has been recognized as a method useful for teratological study.
A teratologic effect of hypervitaminosis A on rat embryos was fist reported by Cohlan.
Giroud and Martinet, Kalter and Warkany have carried out experiments of a similar nature and confirmed and extended the study.
As the animals and methods used in these studies were different, it is very difficult to compare these data each other.
The authors carried out the experiments for the effects of hypervitaminosis A on developing rat embryos with attention to malformations with the following results.
Pregnant female rats were injected intraperitoneally with vitamin A on the 7th or 9th or 11th day after gestation.
Various anomalies were produced in treated rats with varing frequencies. Cleft palate, abnormal tail and microcephalias were most common among them.
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